The role of human cytomegalovirus UL146 gene-α chemokine in cytomegalovirus infection / 国际儿科学杂志

ABSTRACT

Human cytomegalovirus (HCMV) infection is very common in the population. The form of infection usually presents silent or latent infection in the persons with normal immune function, but it can lead to a high mortality in the fetuses and the patients with immune deficiency. At present,the pathogenesis of the congenital infection by HCMV is not very clear. In the α chemokine homologue encoded by HCMV UL146, the variation of the nucleotide and amino acid sequences and the highly conservative domain suggests that this domain is important for HCMV in biological significance. And the study on the gene polymorphism and the function of its encoding protein will play an important role to reveal the pathogenesis of HCMV.