CD44s expression study in colorectal cancer tissues / 中华普通外科杂志
Chinese Journal of General Surgery
; (12): 831-833, 2009.
Article
in Zh
| WPRIM
| ID: wpr-390782
Responsible library:
WPRO
ABSTRACT
Objective To investigate the relationship between standard CD44(CD44s)expression and tumor stage and prognosis in colorectal cancer.Methods CD44s expression was detected by immunohistochemistry in tumor tissues and normal mucosa specimens from 74 cases of primary colorectal cancer.Results Of 74 cases,the expression of CD44s in colorectal cancer tissue and normal mucosa specimens was documented in 42% and 16%,respectively.The expression of CD44s in primary tumors significantly increased in stage Ⅲ and Ⅳ than in stage Ⅰ and Ⅱ(39% vs.6%,x~2=8.46,P<0.01).A statistically significant correlation was observed between the overall survival and CD44s expression(x~2=17.82,P<0.01).Furthermore,a poor prognosis of CD44s-positive tumors was observed in patients with stage Ⅲ and Ⅳ colorectal cancer(x~2=16.23,P<0.01),but not in patients with stage Ⅰ and Ⅱ colorectal cancer(x~2=1.34,P>0.05).Multivariate analysis indicated that TNM stage and CD44s expression were independent predictors of overall survival in colorectal cancer.Conclusion CD44s overexpression is involved in the progress of colorectal cancer and predicting the prognosis.
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of General Surgery
Year:
2009
Type:
Article