IGF-I Exerts an Anti-inflammatory Effect on Skeletal Muscle Cells through Down-regulation of TLR4 Signaling
Immune Network
;
: 223-226, 2011.
Article
in English
| WPRIM
| ID: wpr-39105
ABSTRACT
Although exercise-induced growth factors such as Insulin-like growth factor-I (IGF-I) are known to affect various aspects of physiology in skeletal muscle cells, the molecular mechanism by which IGF-I modulates anti-inflammatory effects in these cells is presently unknown. Here, we showed that IGF-I stimulation suppresses the expression of toll-like receptor 4 (TLR4), a key innate immune receptor. A pharmacological inhibitor study further showed that PI3K/Akt signaling pathway is required for IGF-I-mediated negative regulation of TLR4 expression. Furthermore, IGF-I treatment reduced the expression of various NF-kappaB-target genes such as TNF-alpha and IL-6. Taken together, these findings indicate that the anti-inflammatory effect of exercise may be due, at least in part, to IGF-I-induced suppression of TLR4 and subsequent downregulation of the TLR4-dependent inflammatory signaling pathway.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Insulin-Like Growth Factor I
/
Down-Regulation
/
Cytokines
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Muscle, Skeletal
/
Intercellular Signaling Peptides and Proteins
/
Toll-Like Receptor 4
Language:
English
Journal:
Immune Network
Year:
2011
Type:
Article
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