Effects of Yinxinghuonao capsule on ET,CGRP;NSE and apoptosis neurocyte in rats with cerebral ischemic / 国际中医中药杂志

ABSTRACT

Objective To study the mechanism of Yinxinghuonao capsule on cerebral ischemic stroke(CIS).Methods Fony rats were randomly divided into a Yjnxinghuonao capsule group,a cerebral ischemic group,a sham operated group,and a Nimodipine group,10 rats in each group.The apoptosis cell population and contents of endothelial cell(EC),calcitonin gene-related peptide(CGRP),and neuronspecific enolase(NES)were observed after medication.Results The contents Of ET and NSE in the Yinxing Huonao capsule group were Iess than the cerebral ischemic group and the Nimodipine group,but more than the sham operated group;the content of CGRP in the Yinxing Huonao capsule group was more than the Nimodipine group and the cerebral ischemic group,but less than the sham operated group.The number of apoptosis neurocytes showed a decreasing tendency in the cerebral ischemic group,the Nimodipine group,the YinXing Huonao group and the sham operated group.Conclusion The mechanism of treating cerebral arterial thrombosis with Yinxing Huonao capsule may lies in its functions of increasing CGRP,decreasing ET and delaying apoptosis of neurocytes.