The effects of folk acid and B vitamins supplement on vascular endothelial function in patients of coronary artery disease who undergone interventional therapy / 中国医师进修杂志

ABSTRACT

Objective To evaluate the improvement of endothelial function by folic acid and B vitamins supplement in patients of coronary artery disease who undergone interventional therapy.Methods Eighty patients of coronary artery disease who undergone interventional therapy were divided into two groupscontrol group(40 cases,routine treatment)and treatment group(the others,with routine treatment plus orally taken folic acid and B vitamins,folic acid 15mg/d,vitamin B_(12)75μg/d,vitamin B_6 30mg/d,for 6 months).Plasma homocystine (Hcy)was measured by fluorescence polarization immunoassay and flow-mediated dilation(FMD)of the brachial artery was assessed by high resolution ultrasound before and after 6 months.Results After treatment,the levels of Hcy decreased obviously in treatment group[(8.62±3.51)μmol/L]than that in control group[(12.96±4.62)μmol/L](P<0.01).The FMD was increased significantly in treatment group[(4.22±1.46)%vs (8.74±1.51)%,P<0.01].Conclusions Routine treatment,including aspirin and stafins,significantly improves endothehal function in patients with coronary artery disease.Folic acid and B vitamins supplement may exert beneficial effects on patients with coronary artery disease.