VEGF and Notch pathways in tumor angiogenesis / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 818-821, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-392224
ABSTRACT
VEGF and Notch signaling pathways are important mechanisms in regulation of embryonic vascular development and tumor angiogenesis.Blockade of the VEGF pathway effectively inhibits tumor anglo- genesis and growth.Recent findings indicate that Notch signaling decreases angiogenesis by suppressing endo-thelial tip cell formation.Combination therapy by blocking Notch and VEGF pathways synergistically inhibits tumor growth in preclinical models.Thus,targeting VEGF and Notch pathways may lead to new therapies for clinical application.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2009
Type:
Article
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