The effect of atorvastatin on lowering lipids in elderly patients with type 2 diabetic mellitus plus hyperlipidemia / 中华老年医学杂志

ABSTRACT

Objective To observe the effect of atorvastatin on lowering blood lipid in patients with type 2 diabetic mellitus plus hyperlipidemia. Methods All patients took 10 mg atorvastatin every night for 12 months. The levels of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), serum alanine aminotransferase (ALT), aspartate aminotransferase fAST), fasting blood glucose (FBG), creatinine (Cr), intima media thickness (IMT) of carotid artery (CA), common lilac artery (CIA) and femoral artery (CFA) were examined before and 3, 6, 9, 12 months after the treatment. Results TC [(5.11±0.94) vs. (4.46±0.98) mmol/L, P<0.01] and LDL-C [(3.01±0.78) vs. (2.55± 0.83) mmol/L, P<0. 01] were significantly decreased one year after the treatment. At different detection time points, the levels of LDL-C all reached the therapy standard (<2.59 mmol/L). But TC reached the therapy standard (<4.04 mmol/L) only at nine months after the treatment. IMT of CA, CIA and CFA were at the decreased tendency (P>0. 05). No significant changes were observed in ALT, AST and Cr. Conclusions Atorvastatin may significantly decreased the level of blood lipid with little adverse effect in elderly patients with type 2 diabetic mellitus plus hyperlipidemia, and it also has the effect of protecting the vascular intima.