The suppressive effect of CDS+ CD28-regulatory T cells from spontaneous tolerance models on the acute rejection responses in rat liver transplantation / 中华器官移植杂志

ABSTRACT

Objective To evaluate the suppressive effect of CDS+ CD28-regulatory T cells(Treg)in vivo from spontaneous tolerance models on the acute rejection responses in rat liver transplantation.Methods Spontaneous tolerance models of inbred rat liver transplantation were established.CDS+ CD28-Treg isolated from recipients of spontaneous tolerance models were adoptively transferred into the recipients with acute rejection responses one day before the operation.The survival time and histological changes were observed in the adoptive-transferred models.Results CDS+ CD28-Treg from spontaneous tolerance models(LEW→DA)prolonged the survival time of the recipients in acute rejection models(LEW→BN)(from 14.0±2.2 days to 24.0 ± 3.0 days,P=0.0049),and the severity of rejection was alleviated in liver pathology.Conclusion CDS+ CD28-Treg from spontaneous tolerance models can suppress the acute rejection responses in rat liver transplantation,with antigen-specific properties.