Your browser doesn't support javascript.
loading
Experimental study of low molecular weight heparin inducing acinar cell apoptosis in severe acute pancreatitis / 中国医师杂志
Journal of Chinese Physician ; (12): 342-344, 2009.
Article in Zh | WPRIM | ID: wpr-393198
Responsible library: WPRO
ABSTRACT
Objective To explore the mechanism of LMWH therapy for SAP.Methods 48 wistar rats were random divided into 3 groups,sham group(S group),severe acute pancreatitis group(SAP group)and LMWH therapy group(H group).Serum amylase,IL-6,acinar cell apoptosis and the activity of NF-κB were detected and compared.Results The expression of amylase and IL-6 in SAP group was significantly higher than that in H group(P<0.01).The apoptosis index of acinar cell in SAP group wag significantly lower than that in H group(P<0.01),while the activity of NF-κB in SAP groupwas stronger than that in H group.Conclusions LMWH therapy may ameliorate SAP by inducing acinar cell apoptosis through suppressing the activity of NF-κB.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Chinese Physician Year: 2009 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Chinese Physician Year: 2009 Type: Article