Experimental study of low molecular weight heparin inducing acinar cell apoptosis in severe acute pancreatitis / 中国医师杂志
Journal of Chinese Physician
; (12): 342-344, 2009.
Article
in Zh
| WPRIM
| ID: wpr-393198
Responsible library:
WPRO
ABSTRACT
Objective To explore the mechanism of LMWH therapy for SAP.Methods 48 wistar rats were random divided into 3 groups,sham group(S group),severe acute pancreatitis group(SAP group)and LMWH therapy group(H group).Serum amylase,IL-6,acinar cell apoptosis and the activity of NF-κB were detected and compared.Results The expression of amylase and IL-6 in SAP group was significantly higher than that in H group(P<0.01).The apoptosis index of acinar cell in SAP group wag significantly lower than that in H group(P<0.01),while the activity of NF-κB in SAP groupwas stronger than that in H group.Conclusions LMWH therapy may ameliorate SAP by inducing acinar cell apoptosis through suppressing the activity of NF-κB.
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Index:
WPRIM
Language:
Zh
Journal:
Journal of Chinese Physician
Year:
2009
Type:
Article