High glucose stimulates the expression of transforming growth factor-β1 and fibronectin via SREBP-1 in HKC cells

Jun HAO; Jinping ZHANG; Jiangbo GU; Shuxia LIU; Huijun DUAN

High glucose stimulates the expression of transforming growth factor-β1 and fibronectin via SREBP-1 in HKC cells / 中华内分泌代谢杂志

Jun HAO; Jinping ZHANG; Jiangbo GU; Shuxia LIU; Huijun DUAN.

Chinese Journal of Endocrinology and Metabolism ; (12): 442-444, 2009.

Article in Chinese | WPRIM | ID: wpr-393291

ABSTRACT

ABSTRACT

significantly increased (all P < 0.01). Following SREBP-1 was down-regulated by siRNA, high glucose-stimulated TGF-β1 and FN protein expressions were decreased by 17.9% and 24.6% ,respectively(all P<0.01).

High glucose; HKC cells; SREBP-1; Transforming growth factor-β1; Fibronectin

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Endocrinology and Metabolism Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Endocrinology and Metabolism Year: 2009 Type: Article