A comparison of curative effect between Telbivudine and lamivudine in patients with chronic hepatitis B virus / 中国基层医药

ABSTRACT

Objective To analyze efficacy in patients with chronic hepatitis B virus by telbivudine or lamivu-dine. Methods To collect 100 cases of patients with chronic hepatitis B, according different drugs divided into tel-bivudine group(50 cases)and 50 cases of lamivudine group. Methods The HBV-DNA baseline decline value、HBV DNA below the detection limit、treatment response、HBeAg negative rate、ALT normalization rote、virological response rates、primary treatment failure rate were observed. Results The treatment efficacy at 52 weeks in telbivudine group of HBV-DNA decline in the value of the baseline (6.21og10), HBV DNA below the detection limit (69.6%)、treat-ment response(64.2%), HBeAg negative conversion rate(30.5%)、ALT normalization rate (88.9%)、virologic re-sponse rates (30.5%), primary treatment failure rate(3.6%), higher than the larnivudine group(5.41 og10、43.4%、 86.8%、20.3%、75.1%、18.1%、16.0%) (t =3.65, t =6.55, t =3.95, t =3. 85, t =8.65,t =6.06, t =15.02,P <0.05～0.01). Conclusion The curative effect of telbivudine and lamivudine at 52 weeks achieve better efficacy; curative effect of telbivudine higher than the lamivudine.