Clinical significance and possible mechanism of DJ-1 expression in tumors / 国际肿瘤学杂志

ABSTRACT

DJ-1, ubiquitously expressed in various human tissues, is a multi-functional protein that plays roles in tumors, Parkinson' s disease, breeding and apoptosis. Over- expression of DJ-1 which is identified as a novel oncogene has been reported in several cancer cells. The underlying mechanisms include the anti-oxi-dative stress reaction, down-regulating phosphatase and tensin homolog deleted on chromosome 10 (PTEN) pathway and up-regulating Androgen pathway. However, there are also some evidences show low-expression of DJ-1 in tumor cells.