Significance of changes of plasma levels of homocysteine and adrenomedullin in elderly patients with sudden sensorineural hearing loss / 中华老年医学杂志

ABSTRACT

Objective To explore the relationship between levels of plasma homocysteine (Hcy) and adrenomedullin (ADM) and sudden sensorineural hearing loss (SSHL) in elderly patients. Methods The 80 patients with SSHL but without any treatment were selected as SSHL group, while 80 age-and sex-matched subjects without SSHL were collected as the control group. The levels of plasma Hcy and ADM were measured by fluorescence method and radioimmunoassay, respectively. And the levels of plasma Hey, ADM, total cholesterol (TC) and triglyceride (TG) were compared between the two groups. Results The levels of plasma Hcy, ADM, TC and TG were significantly higher in SSHL group than in control group [(13. 81±2.88) μmol/L vs. (11. 58±2. 80)/xmol/L, (26. 40±3. 20)ng/L vs. (22. 45±2. 80)ng/L, (5.22±0. 87)mmol/L vs. (4. 52±0. 81)mmol/L, (1.80 ±0. 12)mmol/L vs. (1.52±0. 13)mmol/L;t=5. 03, 8. 22, 7.48, 3. 85, all P<0. 01). When the two groups with hypertension were compared, the levels of plasma Hey, ADM, TC and TG were (15.30±2. 77)μmol/L, (29.40±2. 80) ng/L, (5. 48±0. 98) mmol/L and (1.92±0. 18) mmol/L in SSHL group, which were higher than those in control group[(12. 80±2. 62) μmol/L, (25.20± 2. 60) ng/L, (5.01±1.03) retool/L, (1.62±0. 15) mmol/L3 (t=4.03, 7.01, 3.25, 7. 80, all P< 0. 01). There were no differences in systolic and diastolic blood pressure between the two groups(t= 0. 87, 0. 64;P=0. 38, 0. 55).Conclusions The changes of plasma levels of Hey and ADM in the elderly suggest that they could involve in the pathogenic process of SSHL, which may provide referential value for understanding the state of the disease and judging the prognosis