Effects of Xingding injection on the expression MCP-1 in the kidney of diabetic rats / 中国医师杂志

ABSTRACT

Objective To study the protective effects of Ginkgo biloba injection on the renal in diabetic nephropathy rats. Methods The models of diabetic rats were induced by streptozotecin. SD rats (n=18) were randomly divided into three groups, including control group, diabetic group and treated group. After 6 weeks, blood glucose, serum cholesterol and urinary protein were measured respectively. The expression of MCP-1 in the glomerulus was determined by immunohistechemical staining. Results Xingding injection did not influence blood glucose and serum cholesterol, but significantly inhibited expression of MCP-1 and lowered urinary protein excretion. Conclusion Xingding injection has some protective effect, which may be through down-regulating MCP-1 expression.