Effect of estrogens on breast cancer through SDF-1/CXCR4 signaling path-ways / 国际外科学杂志
International Journal of Surgery
;
(12): 51-54, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-395309
ABSTRACT
Breast cancer is a kind of hormone-dependent tumor,the high level of estrogens is an impor-tant risk factor of breast cancer.There is evidence that estrogens through estrogen receptor (ER) signaling pathways and estrogen metabolic products participate in the development and progression of breast cancer.Recentally,studies demonstrated that SDF-1 and its receptor CXCR4 are involved in breast cancer.Estro-gens play an important role in the growth,proliferation and metastasis of breast eaneers through SDF-1/CX-CR4 signaling pathways.These findings may'provide a novel therapeutic target for breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2009
Type:
Article
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