Effect of angiotensin receptor blocker on the expressions of NF-κB PPARγ in adipose tissue of high-fat- diet induced insulin resistant rats / 中华内分泌代谢杂志

ABSTRACT

The expressions of NF-κB and PPARγ were increased in adipose tissue of insulin resistant rats.The angiotensin receptor blocker decreased NF-κB protein expression by 21%,increased PPARγ protein expression by 28%and diminished adipocyte size,suggesting that these findings may be involved in the improvement of obesity-induced inflammation and insulin resisitance.