Relationship between insulin resistance and oxidative stress caused by elevated concentration of free fatty acids / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 205-207, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-395418
ABSTRACT
The relationship between elevated concentration of circulating free fatty acids (FFA) and insulin resistance wag studied,and the pathophysiological mechanism of insulin resistance,especially focused on oxidative stress,was explored.It was found that the elevated circulating FFA level led to insulin resistance in rats, which was partly caused by oxidative stress,and that antioxidative treatment was able to reverse the pathologic change.As a result of enhancing reactive oxygen species production[(886±105 vs 427±42)mmol/L,P<0.05] and disrupting antioxidant[(272±47 vs 561±36)μmol/L,P<0.05],elevated concentration of FFA may induce oxidative stress.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS