Effect of interaction between alcohol dehydrogenase 1B gene polymorphism and obesity on premature coronary heart disease / 中华老年医学杂志

ABSTRACT

Objective To explore the effect of interaction between alcohol dehydrogenase 1B-1/2 (ADH1B·1/2) polymorphism and obesity on premature coronary heart disease (p-CHD).Methods Hospital-based case-control study was conducted.The newly diagnosed CHD patients were recruited as the subjects.One hundred and ninety-seven CHD patients diagnosed before 60 years old for males and 65 years old for females were assigned to the p-CHD case group with other 205 late onset CHD patients as the control group.Body mass index≥28 kg/m2 was defined as the obesity.Polymerase chain reaction-reatriction fragment length polymorphism was used to detect the ADH1B·1/2 polymorphism.Multivariate logistic regression model was performed to adjust the potential confounding factors and odds ratio estimation.Synergy index (S), relative excess risk due to interaction (RERI), and attributable proportion due to interaction (AP) were measured to assess the interaction as departure from additivity.Results There was a positive correlation between ADH1B ·1/2 polymorphism and obesity in patients with p-CAD.S was 2.07, RERI was 1.20, and AP was 36.1%.After adjusting sex, smoking index, alcohol drinking index, serum triglyceride, total cholesterol, diastolic blood pressure, systolic blood pressure and fasting plasma glucose by multiple logistic regression, there was also a positive correlation between ADH1B* 1/2 polymorphism and obesity.S was 2.24, RERI was 1.24, and AP was 38.3% after adjustment.Conclusions The interaction between ADH1B*1/2 polymorphism and obesity has a positive effect on the p-CAD in this studied population.