Intraamniotic ethacridine lactate instillation versus mifepristone and misoprostol combination in 16-28 weeks termination of pregnancy / 中国医师进修杂志

ABSTRACT

Objective To observe oral mifepristone and vaginal misoprostol combination (medical induction labor)for 16-28 weeks termination of pregnancy and compare the effectiveness with intrannmiotic instillation of ethacridine lactate (EL) in this setting. Methods 16-28 weeks gestation, total 100 pregnant women from February 2006 to June 2007 were elected. Two groups were divided randomly group A (intraamniotic injection of ethacridine lactate)and group B(mifepristone and misoprostol combination). Main outcome measures: success rate, induction-delivery interval, intrapartum hemorrhage, length of stay complications. Results Termination of pregnancy was successful in 38 cases (76%), induction-delivery interval was (42.0±5.8) h, length of stay was (96±6) h and intrapartum hemorrhage was (110.6±6.5) ml in group A. The matched pair analysis revealed termination of pregnancy was successful in 49 cases (98%), there were significantly shorter induction-delivery interval (12.5±4.5) h, length of stay (72±4) h and lower intrapartum hemorrhage (46.3±5.6)ml in group B (P<0.05). Conclusions Compared to intraamniotic instillation of ethacridine lactate, oral mifepristone and vaginal misoprostol combination for 16-28 weeks termination of pregnancy had higher successful rate, shorter induction-delivery interval, length of stay and lower intrapartum hemorrhage.