Paradoxical role of Kupffer cells on ischemia/reperfusion injury in liver transplantation / 国际外科学杂志
International Journal of Surgery
;
(12): 94-97, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-396476
ABSTRACT
Kupffer cells, the resident macrophages of the liver, play an important role in ischemia/reperfusion(L/R)injury in liver transplantation. 1schemic liver is reperfused through portal vein, and then Kupffer cells are activated. The liver is damaged by the released reactive oxygen species, inflammatory mediators and cytokines. On the other hand, upregulation of HO-1, induced by the activated kupffer cells, exerts a cytoprotective function for the IYR injury in liver transplantation models. Thus, Kupffer cells play the dual role on L/R injury in liver transplantation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Surgery
Year:
2009
Type:
Article
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