Mitogen Activated Protein Kinase Family Proteins and c-jun Signaling in Injury-induced Schwann Cell Plasticity
Experimental Neurobiology
;
: 130-137, 2014.
Article
in English
| WPRIM
| ID: wpr-39653
ABSTRACT
Schwann cells (SCs) in the peripheral nerves myelinate axons during postnatal development to allow saltatory conduction of nerve impulses. Well-organized structures of myelin sheathes are maintained throughout life unless nerves are insulted. After peripheral nerve injury, unidentified signals from injured nerves drive SC dedifferentiation into an immature state. Dedifferentiated SCs participate in axonal regeneration by producing neurotrophic factors and removing degenerating nerve debris. In this review, we focus on the role of mitogen activated protein kinase family proteins (MAP kinases) in SC dedifferentiation. In addition, we will highlight neuregulin 1 and the transcription factor c-jun as upstream and downstream signals for MAP kinases in SC responses to nerve injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Peripheral Nerves
/
Phosphotransferases
/
Plastics
/
Protein Kinases
/
Regeneration
/
Schwann Cells
/
Axons
/
Transcription Factors
/
Action Potentials
/
Neuregulin-1
Limits:
Humans
Language:
English
Journal:
Experimental Neurobiology
Year:
2014
Type:
Article
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