Evaluation of modified vaccinia virus Ankara expressing VP2 protein of infectious bursal disease virus as an immunogen in chickens
Journal of Veterinary Science
;
: 199-201, 2012.
Article
in English
| WPRIM
| ID: wpr-39672
ABSTRACT
A recombinant modified vaccinia Ankara (MVA) virus expressing mature viral protein 2 (VP2) of the infectious bursal disease virus (IBDV) was constructed to develop MVA-based vaccines for poultry. We demonstrated that this recombinant virus was able to induce a specific immune response by observing the production of anti-IBDV-seroneutralizing antibodies in specific pathogen-free chickens. Besides, as the epitopes of VP2 responsible to induce IBDV-neutralizing antibodies are discontinuous, our results suggest that VP2 protein expressed from MVA-VP2 maintained the correct conformational structure. To our knowledge, this is the first report on the usefulness of MVA-based vectors for developing recombinant vaccines for poultry.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Poultry Diseases
/
Vaccinia virus
/
Viral Vaccines
/
Viral Structural Proteins
/
Cells, Cultured
/
Chickens
/
Specific Pathogen-Free Organisms
/
Birnaviridae Infections
/
Infectious bursal disease virus
/
Fibroblasts
Limits:
Animals
Language:
English
Journal:
Journal of Veterinary Science
Year:
2012
Type:
Article
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