Clinical distribution and antibiotics resistance of 576 strains isolated from blood specimens / 中华临床感染病杂志

ABSTRACT

Objective To investigate the distribution and antibiotics resistance in blood culture isolates.Methods The clinical isolates of blood specimens from patients in the First Affiliated Hospital of Anhui Medical University during 2004 to 2006 were identified anti the drug resistance to antimierobial agents was tested.The results were analyzed and compared with those during 1986 to 1998.Results A total of 576 strains were isolated from 6203 blood specimens,among which gram positive cocci and gram negative bacilli account for 57.8%(333/576)and 31.4%(181/576),respectively.The frequent isolates were coagulase negative Staphylococcus,Escherichia coli,Staphylococcus aureus,hemolytic Streptococcus viridans,Klebsiella pneumoniae and fungi.The methicillin-resistant coagulase negative Staphylococci(MRCNS)accounted for 78.3%(155/198).Gram negative bacilli were highly susceptible to imipenem,piperacillin/tazobactam and amikacin.Conclusions The incidence of bloodstream infections caused by MRCNS,gram negative bacilli producing ESBLs and fungi are increasing.The clinical isolates from blood have hish resistance to the first line antibiotics.