Lectin-Like Oxidized Low-Density-Lipoprotein Receptor-1 and Atherosclerosis / 国际脑血管病杂志

ABSTRACT

Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a specific receptor of oxidized low-density lipoprotein (oxLDL) expressed in endothelial cells. It is a type Ⅱ single-chain transmembrane protein and belongs to C-type lectin family. LOX-1 leads to the injury of endothelial cells by mediating oxLDL, and plays a role in the initiation and progression of atherosclerosis, hypertension, thrombosis. This article reviews the association between LOX-1 and atherosclerosis.