Inhibition of IFN-γ receptor signaling by Hepatitis C Virus non-structural protein NS4B / 中国医师杂志
Journal of Chinese Physician
;
(12): 1470-1472, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-397280
ABSTRACT
Objective To study the influence of NS4B on host defense system. Methods After cell line stably expressed NS4B was established, cell expression profiling caused by NS4B was studied using DNA microarray, and the results of microarray were verified via IFNGR1 fluorescence intensity analysis. Results The data showed that HCV-NS4B could suppress host defense system-associated gene ex-pression, in particular, IFN-γsignal transduction-related genes. Conclusion NS4B could play a role in persistence and resistance to IFN therapy in HCV infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2008
Type:
Article
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