A study on cognitive function and event related potential in chronic alcoholism patients / 中华行为医学与脑科学杂志

ABSTRACT

Objective To evaluate cognitive function of chronic alcoholism patients.Methods The Wechsler Adult Intelligence Scale-Revise in China(WAIS-RC) and WMS-RC,including intelligence quotient,logical Memory.visual memory and stroop test,were investigated and P300 component of auditory event-related potential (ERP,P300),especially the subcomponents P3a and P3b were examined in 100 chronic alcoholism patients,and 70 healthv people matched in age,sex and educational level as controls.Results Compared with controls,the score of Verbal intelligence quotient(VIQ),Performance intelligence quotient (PIQ),Full-scale intelligence quotient (FIQ),logical memory,visual memory (immediate and delayed),and stroop test were significant lower (P <0.05.P＜O.01)in chronic alcoholism patients,but the latencies of P3a and P3b wave were significantly prolonged.the amplitude of P3a and P3b wave were significantly decreased in chronic alcoholism patients.Conclusion Chronic alcoholism patients have cognitive function impairment,and P300 is a more sensitive to discover the impairment of the cognitive function.