DNA flow cytometry in pheochromocytoma and paraganglioma
Yonsei Medical Journal
;
: 249-257, 1992.
Article
in English
| WPRIM
| ID: wpr-39782
ABSTRACT
Flow cytometric DNA analysis was performed on 19 adrenal pheochromocytomas and 6 extra-adrenal paragangliomas in parallel with clinical and histopathological review to determine the usefulness of this technique to predict biologic behavior of these tumors. In pheochromocytomas and paragangliomas, tetraploidy or near-tetraploidy occurred in 32% and 33% and aneuploidy in 10% and none respectively. A case of malignant pheochromocytoma had diploid DNA content. Occurrence of aneuploidy or tetraploidy is frequent in clinically benign tumors in conjunction with a marked degree of nuclear atypia and cannot be a predictor of malignancy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraganglioma
/
Pheochromocytoma
/
Ploidies
/
DNA, Neoplasm
/
Age Factors
/
Adrenal Gland Neoplasms
/
Flow Cytometry
/
Middle Aged
/
Mitosis
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
1992
Type:
Article
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