Detection and significance of serum ICAM-1 and E-selectin in patients with chronic obstructive pulmonary disease / 中国基层医药

ABSTRACT

Objective To study the detection and significance of serum ICAM-1 and E-selectin in patients with chronic obstructive pulmonary disease (COPD).Methods Double antibody sandwich quantitative enzyme fined immunosorbent assay (ELISA) method was used to measure the serum levels of serum ICAM-I and E-selectin in 60 patients with COPD,52 exacerbated patients,52 stable patients and 30 normal control subjects.Results The levels of serum ICAM-1 and E-selectin in COPD group and exacerbated patients were significantly higher than those in normal controls (P＜0.01) ; these in stable patients were significantly lower than those of exacerbated patients (P＜0.01),and significantly higher than those exacerbated patients(P＜0.05).Conclusion ICAM-1 and E-selectin were involved in occurrance and development process of COPD.