Application of Pre-S1 antigen in the diagnosis of hepatitis B / 中国基层医药

ABSTRACT

Objective To analyze and compare the Pre-S1 antigen and the serum markers to discuss the clinical significance of the Pre-S1 antigen of HBV.Methods The serum markers and the Pre-S1 antigen of HBV were detected by ELISA.Result By analyzing the serum markers in different combination modes,we found that the detection rate of the Pre-S1 antigen in different combination modes are94% ( in the HBeAg positive mode) ; 15.6%(in the HBeAg negative mode) and negative in the mode both HBsAg and HBeAg are negative.Conclusions The Pre-S1 antigen of HBV has a coherence with HBeAg to a large extent,and has contact relations with the exist and replicate of HBV and can reflect the replication of HBV.The detection of the Pre-S1 antigen can help the diagnosis of HBV infection.