Changes of soluble interleukin-2 receptor and high sensitivity C-reactive protein in renal allograft recipients / 中国医师杂志

ABSTRACT

Objective To observe the changes of soluble interleukin-2 receptor(slL-2R) and high sensitivity C-reactive (hs-CRP) protein in renal allograft recipients and its relationship with rejective response of renal allograft. Methods The concentration of sIL-2R and hs-CRP were detected in 91 patients with renal allograft recipients and 100 health controls. CRP was measured by particle enhanced immuo-turbidimetric method, sIL-2R was detected by ELISA. Results The concentration of sIL-2R and hs-CRP in the recipients with acute rejec-tion was significantly higher than those without graft rejection and health controls. The concentration of hs-CRP in the recipients with chronic rejection was higher than those without graft rejection and health controls. There was no evidence of significant changes in the concentration of sIL-2R and hs-CRP between the health control group and the recipients without graft rejection. Conclusion slL-2R and hs-CRP might play an important role in graft rejection. The measurement of sIL-2R and hs-CRP is important for the diagnosis of graft rejection.