Correlation Analysis of the Expressions of IL-6 , TNF-αand TGF-β in Experimental autoimmune Encephalomyelitis in Rats / 中国医师杂志
Journal of Chinese Physician
;
(12): 1314-1317, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-397984
ABSTRACT
Objective To explore the mechanism of IL-6 in EAE. Methods 25 female Wistar rats were randomly divided into 2 groups, EAE group( n=15 ) and normal control group( n=10). The expression of IL-6, TNF-αtand TGF-β of the two groups rots were ob-served by immunohistochemistry staining, and then correlation analysis of the expression of IL-6, TNF-αtandTGF-β was made. Results There was negative correlation between gray scale of IL-6 and symptom scores( r=-0.953, P>0.05). IL-6 and TGF-β had no statistical-ly significant correlation ( r=-0.492, P>0.05). There was negative correlation between gray scale of TNF-α and symptom scores( r=-0.978, P<0.05), and both of the correlation between TNF-α and TGF-β ( r=-0.502, P>0.05), TGF-β and scores( r=0.470,P>0.05 ) were not statistically significant. Conclusions IL-6 may participate in EAE as a inflammatory factor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2008
Type:
Article
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