Relationship between hypoxia reaction and colon carcinoma / 国际肿瘤学杂志

ABSTRACT

Colon cancer possesses hypoxia microenvironment. The essence of hypoxia is a kind of reaction and adaptive change. Hypoxia reaction plays an important role in the genesis and development of colon cancer,including the effect produced by hypoxia inducible factor-let and reactive oxygen species under hypoxia reaction and influence on cell apoptosis and energy metabolism directly generated by hypoxia reaction in colon cancer. The alteration of hypoxia reaction in colon carcinoma as tumor adjunctive therapy becomes focus research in the field of colon cancer.