A preliminary study of acute gastrointestinal infection-associated functional dyspepsia / 中华内科杂志

ABSTRACT

To investigate the clinical characters and the possible pathogenesis of post infectious functional dyspepsia(PI-FD).Methods 550 patients suffered with acute gastrointestinal infection were followed-up for half year to evaluate the prevalence and symptoms of PI-FD.Meanwhile,thirty patients with non-special functional despepsra(NS-FD)and twenty healthy volunteers were enrolled.The number of mast cells,the total amount of tryptase and histamine released were determined.Furthermore,the ultra-structure of mast cells was observed by electron microscope,and the number of mast cells located within 5μm of nerve fibers was also countered.Results The prevalence of PI-FD is about 6.7%(35/522)after acute gastrointestinal infection in half year.The scores of epigastric pain,epigastric burning sensation and early satiety in patients with PI-FD were significantly higher than those in patients with NS-FD(P<0.05 for all),so did the scores of histological chronic inflammation in gastric mucusa(P<0.05).There is no significant difference in the number of mast cells between patients with PI-FD and NS-FD(P>0.05).However,the number of activated mast cells in patients with PI-FD is significantly higher than that in patients with NS-FD.The total amount of tryptase in gastric mucoss and the histamine released in patients with PI-FD is higher than that in patients with NS-FD and healthy volunteers(P<0.05 for all).Under the electron microscope,the number of mast cells located within 5μm of nerve fibers in PI-FD patients was significant higher than that in other two groups(P<0.05 forall).Conclusions PI-FD is probably a specific type of functional dyspepsia.Epigastric pain,epigastric burning sensation,and early satiety are the major symptoms in these patients.Mast cells maybe involved in the pathogenesis of PI-FD.