Influence of leptin signal transducting system on ovary function in the db/db mouse / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
;
(12): 428-429, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-398996
ABSTRACT
Four genotypic mice were constructed, by ovary transplantation, with body leptin receptor (LR) + and ovary LR - in Group A, body LR + and ovary LR + in Group B, body LR - and ovary LR + in Group C, as well as body LR - and ovary LR - in Group D respectively. Mice in C and D groups showed significant differences in glucose and fat metabolism as well as ovarian function as compared with A and B groups. Leptin signal transducting system exists in the ovary. Ovarian failure was induced by hyperlipidemia and lowered gonadotropin levels, but not by defective leptin signal within ovaries in the db/db mice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrinology and Metabolism
Year:
2008
Type:
Article
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