Proliferative responses of peripheral blood mononuclear cell to various HBV antigen in the patients with hepatitis B / 中华传染病杂志
Chinese Journal of Infectious Diseases
;
(12): 181-183, 1999.
Article
in Chinese
| WPRIM
| ID: wpr-399002
ABSTRACT
Objective To investigate the role of cell mediated immunity in HBV infection.Methods tive responses of peripheral blood mononuclear cell(PBMC)to hepatitis B virus antigen HBcAg,HBehg and HBsAg were studied in 20 patients with acute hepatitis B and 23 patients with chronic hepatitis B as well as 20 heath normal donrors.Results Patients with acute hepatitis B showed stronger proliferative responses of PBMC to HBV antigen than patients with chronic hepatitis B as wdl as normal donors.The responses to HBcAg and HBeAg were stronger than that to HBsAg in both acute and chronic group.It was also found that cellular pro|ifertive response,which showed no correlation with ALT level,was significantly increased in the patients with HBV DNA+or/and HBeAg+.Conclusion The results indicate that cellular immune responses to HBV antigens exist in peripheral blood of patients with hepatitis B and potentially play an essential role not only in eliminating virus but also in the pathogenesis of hepatitis B.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Infectious Diseases
Year:
1999
Type:
Article
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