Your browser doesn't support javascript.
loading
Progress in differentiation of hepatocytes from embryonic stem cells / 国际生物医学工程杂志
Article in Zh | WPRIM | ID: wpr-399339
Responsible library: WPRO
ABSTRACT
Acute liver failure and end-stage liver diseases are llfe-threatening.So far,orthotopic liver transplantation is the unique treatment available for these late-stage liver diseases,which,however,is limited by the lack of donor liver.While hepatocyte transplantation,bioartificial liver and tissue engineered liver are potential alternative treatments,the limited availability of functional hepatoeytes is the major hurdle.Due to their extensive capacity for self-renewal and pluripotency to differentiate into cells,embryonic stem cells represent a potential unlimited cell source for therapy.The clinical application of embryonic stem cells in liver diseases requires well-defined and efficient protocols for differentiation,characterization and purification in vitro.Hepatic differentiation of embryonic stem cells in different culttire systelns and the problems remained are reviewed in this article.
Key words
Full text: 1 Index: WPRIM Type of study: Guideline Language: Zh Journal: International Journal of Biomedical Engineering Year: 2008 Type: Article
Full text: 1 Index: WPRIM Type of study: Guideline Language: Zh Journal: International Journal of Biomedical Engineering Year: 2008 Type: Article