BDNF/NF-κB signal pathway activation in rats with febrile seizures / 中国小儿急救医学
Chinese Pediatric Emergency Medicine
;
(12): 348-352, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-399531
ABSTRACT
Objective To study the change of BDNF/NF-κB signal pathway induced by repeated febrile seizures.Methods Fifty-one 21 d male rats were randomly divided into three groupsnormal control group(n=14),hyperthermal control group(n=19)and febrile seizure group(n=18).The febrile seizure model was devdoped by warrn water immersion[(45.0±0.3)℃].BDNF and NF-κB were measured by enzyme hnked immunosorbent assay(ELISA)and immunohistochemistry.Results The levels of BDNF in serum and hippocarnpus in FS group were higher than those in NC group(P<0.01)and in HC group(P<0.01).In FS group,the OD of the BDNF positive neuron was higher than that of NC group(P<0.01)and HC group(P<0.01);the OD of the NF-κb positive neuron in FS group was higher than that of NC group (P<0.01)and HC group(P<0.01),the OD of the NF-κB positive neuron in HC group higher more than in NC group(P<0.01).There was positive correlation between BDNF expression and NF-κB activation(r=0.78.P<0.01).Conclusion The expression of BDNF and NF-κB were obviously increased in FS group and they are positively correlated,suggesting that the BDNF/NF-κB signal pathway may be activated after febrile seizure.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Pediatric Emergency Medicine
Year:
2008
Type:
Article
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