Expression and significance of Paxillin and VCAM-1 proteins in esophageal carcinoma / 中国综合临床
Clinical Medicine of China
; (12): 757-759, 2008.
Article
in Zh
| WPRIM
| ID: wpr-399543
Responsible library:
WPRO
ABSTRACT
Objective To study the expression of Paxillin and VCAM-1 in esophageal carcinoma and the relationship between the expression of Paxillin, VCAM-1 and carcinogenesis and progression of esophageal carcinoma. Methods Paxillln and VCAM-1 expression were detected in 24 normal esophageal mucosa and 94 primary tumor tissues with SP immunohistochemistal method. Results The expression rate of PaxiUin was related to invasive depth (P <0.01) ,clinical staging (P <0.01) and metastasis of lymph node (P <0.05). The expression rate of VCAM-1 was related to invasive depth (P < 0.01) ,clinical staging (P < 0.01) and metastasis of lymph node (P<0.05). There was a positive correlation between Paxillin and VCAM-1 expression in this study (r = 0. 247 ,P < 0.05). Conlusion Paxillin and VCAM-1 are over expressed in esophageal carcinoma. They can be used as valuable biomakers to evaluate biological characteristics in esophageal carcinoma.
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WPRIM
Language:
Zh
Journal:
Clinical Medicine of China
Year:
2008
Type:
Article