Effects of Sites and Mechanisms of Middle Cerebral Artery Occlusion on Lesion Patterns and the National Institutes of Health Stroke Scale / 国际脑血管病杂志

ABSTRACT

Objective:To analyze the independent and comprehensive effects of the sites and mechanisms of middle cerebral artery(MCA)occlusion on cerebral infarction patterns and the National Institutes of Health Stroke Scale (NIHSS)scores andto investigate the possible related mechanisms and their potential values to the selection of patieras for thrombolysis.Methods:Sixty-six patients with new cerebral infarction caused by MCA occlusion were enrolled.The sites of MCA occlusion were classified into the origin of the MCA(type Ⅰ),the MCA trunk distal to the lenticulostriate arteries(type Ⅱ)and the branches of the MCA(type Ⅲ)the mechanisms of cerebral infection were categorized as thrombotic and embolic.Cerebral infarction lesion patterns were determined according to diffusion-weighted image(DWI).NIHSS scores were evaluated within 24 hours after stroke onset.The independent and comprehensive effects of the sites and mechanisms of MCA occlusion on cerebral infarction lesion patterns and the NIHSS were analyzed.Results:Cerebral infarction involved a larger range and NIHSS scores were higher in patients with occlusion at the origin of MCA and embolic occlusion of the MCA trunk distal to the lenticulostriate arteries.The analysis of the combination of the sites and mechanisms of occlusion could conduct further stratification for patients with cerebral infarction caused by MCA occlusion compared with univariate analysis.Conclusion:The analysis of the combination of the sites and mechanisms of occlusion better stratifies patients with cerebral infarction caused by MCA occlusion.It may be help to select patients for thrombolytic therapy.