Airway wall thickness and pulmonary functions in patients with bronchial asthma: Assessment with high resolution computed tomography (HRCT) / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 494-501, 2003.
Article
in Korean
| WPRIM
| ID: wpr-39987
ABSTRACT
BACKGROUND:
The presence of airway wall thickening and its relationship with pulmonary functions or airway hyperresponsiveness (AHR) have not yet been sufficiently clarified in bronchial asthma.OBJECTIVE:
We investigated the relation of airway wall thickness to the pulmonary functions and AHR in patients with asthma.METHODS:
After baseline measurement of pulmonary functions and PC20 in 24 patients, we measured airway wall thickness (T), internal diameter (d) using HRCT and calculated external diameter (D)[(D)=(d)+ 2x(T)]. We used the T/D ratio as a parameter for comparisons with pulmonary functions and PC20.RESULTS:
We measured total 185 airways (upper;92, lower;93). The mean T/D ratio of small airways (diameteror=2mm;n=74) (0.324 +/- 0.028 vs 0.274 +/- 0.033, p<0.001). The mean T/D ratio of each subjects showed significant negative correlation with FEV1(% of predicted) in total (r=-0.407, p=0.048) and small airways (r=-0.468, p=0.024). PC20 showed a tendency of weak negative correlation with mean T/D ratio in small airways (r=-0.290, p=0.179).CONCLUSION:
The thicker the airway wall is, the lower the FEV1 (% of predicted) in patients with bronchial asthma. Airway wall thickening occurred predominantly in the small airways.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
Limits:
Humans
Language:
Korean
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
2003
Type:
Article
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