Clinical study on non-motor symptoms of Parkinson disease / 中华老年医学杂志

ABSTRACT

Objective This study was designed tO survey the prevalence,distribution of nonmotor symptoms(NMS)in Parkinson disease(PD)and their relationship with disease severity and duration. Methods We used Unified Parkinson Disease Rating Scale(UPDRS)part Ⅲ,V,the PD NMS Questionnaire,activities of daily living(ADL)and mini-mental state examination(MMSE)to assess motor and non-motor symptoms in 81 patients with Parkinson disease. Results In PD,a range of NMS occurred across all disease stages.Each PD patient had 7 different NMS on average.The problems of remembering thing,constipation and nocturia ranked top 3 of NMS in patients with PD.There was a significant association of total NMS score with H-Y stage(P<0.01)and UPDRS Ⅲscore(P<0.01).There was a negative correlation between NMS score and ADL score(P<O.05),but no relationship of total NMS score was found with disease age,duration,sex distribution,daily dose of L-dopa or subtype of PD. Conclusions NMS in PD are common and frequent.PD-NMS affect patients'quality of life,just like motor symptoms,and should be well recognized and treated.