Cationic Trypsinogen Gene Mutation in Patients with Chronic Idiopathic Pancreatitis / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 41-46, 2004.
Article
in Korean
| WPRIM
| ID: wpr-40062
ABSTRACT
BACKGROUND/AIMS:
Mutation of Cationic trypsinogen gene is clearly associated with hereditary pancreatitis and plays an important role in the pathogenesis of pancreatitis. According to literature, this mutation is occasionally occurred in patients with pancreatitis in Western countries and Japan. The aim of this study was to find out whether the mutation was observed in Korean patients with chronic idiopathic pancreatitis.METHODS:
Peripheral blood samples of 11 patients with chronic idiopathic pancreatitis were collected consecutively, and DNA was extracted from the samples. Polymerase chain reaction was performed in exon 2 and 3 of cationic trypsinogen gene. Then, DNA products were purified and sequenced.RESULTS:
The mutation was not found in exon 2 and 3 of cationic trypsinogen gene in these patients.CONCLUSIONS:
There was no cationic trypsinogen mutation in Korean patients with chronic idiopathic pancreatitis. Further large sampled cohort study is needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pancreatitis
/
Trypsinogen
/
English Abstract
/
Trypsin
/
Polymerase Chain Reaction
/
Chronic Disease
/
Mutation
Type of study:
Observational study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2004
Type:
Article
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