Matrix Metalloproteinases and Hemorrhagic Transformation / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12): 285-288, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-400687
ABSTRACT
Thrombolysis can effectively treat ischemic stroke, but it has the risk of resulting in hemorrhagic transformation. A number of studies have suggested that hemorrhagic transforma-tion is closely correlated with matrix metalloproteinase mediated disruption of blood-brain barrier and the increase of vasopermeability. The increase plasma matrix metalloproteinase(MMP) -9 can be used as an independent predictor of hemorrhagic transformation. Using MMP inhibitors during the early cerebral ischemia may reduce the incidence and severity of hemor-rhagic transformation, however, it needs to be further validated.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2008
Type:
Article
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