Memantine and Vascular Dementia / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
;
(12): 289-292, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-400734
ABSTRACT
Excitatory amino acid toxicity is one of the mechanisms of vascular dementia. Gluta-mate is the major excitatory neurotransmitter in brain. Memantine, a moderate affinity, uncom-petitive and voltage-dependent N-methyl-D-aspartate (NMDA) receptor blocker, can block NMDA receptor-induced intracellular calcium overload and prevent excitotoxicity. It can be used in the treatment of vascular dementia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Cerebrovascular Diseases
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS