Expression and clinical significance of HER2 and p16 in endometrial carcinoma / 中国医师进修杂志

ABSTRACT

Objective To study the expressions of HER2 and p16 in human endomctrial carcino-ms,and the relation with FIGO stage,cell differentiated degree.Methods Endometrial cancer was 46 cas-es,atypical hyperplasia was 10 cases,endometrial hyperplasia was 10 cases,normal endometrium was 20cases.The immunohistochemical S-P methods were used to detect the expression of HER2 and p16.Results The expression ofHER2in endometrial cancerwasmuch higherthan others(P＜0.01),moreover,the expression was increased with the increase of clinical stages(P ＜ 0.05) and the decrease of differentiated degree(P ＜ 0.05). The expression of p 16 in endometrial cancer was lower than others (P ＜ 0.05 ), and the expres-sion was reduced with the increase of clinical stages(P ＜ 0.01 ) and the decrease of differentiated degree(P ＜0.05).There was negative correlation between expression of HER2 and p16 in uterine endometrial cancer(r ＝ -0.4213, P＜ 0.01 ). Conclusions The expression of HER2 and p16 in endometrial cancer is associat-ed with the biological behavior of endometrial cancer. HER2 and p16 may be used as objective predictable indicators of endometrial cancer to guide the postoperative treatment.