Expression and significance of VEGF-D and MMP-2 in pancreatic carcinoma / 中国医师杂志
Journal of Chinese Physician
;
(12): 291-294, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-401354
ABSTRACT
Objective To investigate the expression of VEGF-D and MMP-2 and explore their relationship with tumor invasion and local metastasis in pancreatic carcinoma.Methods The expression of VEGF-D and MMP-2 in 30 patients with pancreatic carcinomas and 6 cases with normal pancreatic tissues were detected by SABC immunohistochemical method.Results The positive rates of VEGF-D and MMP-2 proteins were 60%(18/30)and 66.7%(20/30)respectively,no expression of VEGF-D and MMP-2 was detected in normal pancreatie tissues.The expression of VEGF-D was significantly correlated with lymph node metastasis(P<0.05),and the expression of MMP-2 was significantly correlated with lymph node metastasis and tumor local invasion(P<0.05).The expression of VEGF-D protein Was positively correlated with MMP-2 protein(rs=0.54,P<0.01).Conclusions There is a significantly positive correlation between high expression of VEGF-D and MMP-2 proteins in pancreatic carcinoma,and they may contribute to the invasive properties of pancreatic cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Chinese Physician
Year:
2008
Type:
Article
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