Significance and detection of levels of IL-8,TNF-α in serum of patients with aplastic anemia / 中国基层医药
Chinese Journal of Primary Medicine and Pharmacy
; (12): 198-199, 2008.
Article
in Zh
| WPRIM
| ID: wpr-402006
Responsible library:
WPRO
ABSTRACT
Objective To investigate the significance of levels of IL-8,TNF-α in serum of patients with aplastic anemia(AA).Methods Serum levels of IL-8 and TNF-α in 45 patients and 30 normal controls were measured by enzyme linked immunosorbent assay.Results The serum levels of IL-8,TNF-α increased significantly in AA and acute AA(AAA)group than in the control group(P<0.05),there was no statistical significance between chronic AA(CAA)group and the control group(P<0.05),and the levels in AAA group were much higher than in CAA group(P<0.05).The serum level of IL-8 was positively related to TNF-αin AA group(r=0.682,P<0.05).Conclusion There are immunological disorders in patients with AA and the overproduction of IL-8,TNF-α might be involved in the immunopathogenesis of AA,AAA.
Full text:
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Index:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Journal of Primary Medicine and Pharmacy
Year:
2008
Type:
Article