Protein MG29 and skeletal muscle aging / 中国组织工程研究

ABSTRACT

OBJECTIVE: To review research advances of Mitsugumin-29 (MG29) protein and its relationship with skeletal muscle aging. DATA SOURCES A computer-based online search of CNKI (http//www.chkd.cnki.net), Duxiu (http//edu.duxiu.com) and SSReader (http//edu.sslibrary.com) with key words of MG29 and skeletal muscle aging in Chinese; Elsevier SD (httpllwww.sciencedirect.com) and Springer Link (httpllspringer.metapress.comlhomelmain.mpx) with key words of MG29, aging skeletal muscle, sarcopenia. In addition, related articles were manually searched.DATA SELECTION Inclusion criteria location, structure and function of MG29; MG29 and skeletal muscle aging; MG29 and exercise; related articles aimed to the content with large impact factor. Exclusion criteria repetitive studies or Meta analysis.MAIN OUTCOME MEASURES: MG29 has close relationship with skeletal muscle aging.RESULTS: In recent years, extensive researches have been conducted to discover the mechanisms underlying skeletal muscle aging by investigators home and abroad from histology, biochemistry and molecular biology. It is universally accepted that the changes in the cellular homeostatic capacity for Ca~(2+) is a core factor in regulating excitation contraction coupling, and it dynamic balance is the major cause of skeletal muscle aging. MG29, which is located in the membrane of transverse tubule, is a protein that is newly found to modulate Ca~(2+) signal resembling the synaptophysins. Studies have shown that the level of MG29 reduced 50% in old skeletal muscle. Similar phenotypes to aging skeletal muscles have been observed in adolescent muscle null for MG29 which is involved in muscle weakness, increased susceptibility to muscle fatigue, fragmented sarcoplasmic reticulum networks, swollen transverse tubule system, altered calcium sparks, segregated Ca~(2+) reserve and so on. These suggest that MG29 and aging skeletal muscle are closely related.CONCLUSION: It has been confirmed that MG29 is highly correlated with aging skeletal muscle. However, studies concerning MG29 improvement to delay skeletal muscle aging should be conducted subsequently.