Meniscus injury repair by xenogenic or tissue-engineered meniscus replacement therapy / 中国组织工程研究

ABSTRACT

BACKGROUND: Meniscus injury is a common sports injury of knee joint. Severe meniscus injury is difficult for clinical treatment due to the blood supply features. Effective repair of meniscus injury can prevent osteoarthritis of knee joint. OBJECTIVE: To review meniscus injury repair and transplantation replacement treatment of meniscus injury.METHODS: A computer-based online search of CNKI (www.cnki.net) and Medline database (www.pubmed.com) was performed for related articles published between January 2000 and March 2009, with the keywords "meniscus, repair, transplanted replacement therapy" in Chinese and English. Unrelated and repetitive studies were excluded. A total of 29 articles were included.RESULTS AND CONCLUSION: There are a number of treatment for meniscus injury, and indications and appropriate repair methods are very important. Xenogenic meniscus transplantation and tissue-engineered meniscus provide novel approach for meniscus injury repair, in particular the repair of avascular zone. However, the two methods require validation of immunology,epidemiology, anatomy, biomechanics, and clinical effect.