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Effects of fluorid on biomechanical parameters of the femur in young rats / 中国组织工程研究
Article in Chinese | WPRIM | ID: wpr-402849
Responsible library: WPRO
ABSTRACT

BACKGROUND:

Fluoride treatment of osteoporosis has been controversial.Literatures addressing the effect of fluoride on bone bio-mechanical parameters of femur in young rats are few.

OBJECTIVE:

To study the effects of fluoride on bone biomechanical parameters of femur in young rats.

METHODS:

Ninety 2-month-old SPF Sprague Dawley rats,half male and female,were randomly divided into 9 groupscontrol group(young,adult and long-time)and drug-administered group(young high-fluoride,young low-fluoride,adult high-fluoride,adut low-fluoride,long-term high-fluoride and long-term low-fluoride).Rats in the control group were orally administered with physiological saline,while in the drug-administered group were given orally with different dose fluoride at the corresponding times.After experiment,rats were sacrificed under anaesthesia.Three-point bending test was performed at the left femur.The effects of fluoride on maximum load and rigidity of femur were measured.RESULTS AND

CONCLUSION:

Compared with young control group,the maximum load and the rigidity of femur in the young high-fluoride group were decreased by 13.18%and 13.61%,respectively(P<0.05),which had no dramatically difference in the young low-fluoride group.Compared with long-term high-fluoride group,the maximum load and the rigidity offemur in the young high-fluoride were decreased by 17.22%and 17.17%(P<0.05),which were obvious increased in the long.term low-fluoride grou by 18.33%and 19.15%,respectively(P<0.05).The maximum load and the rigidity of femur were strengthened in the adult high-fluoride and adult low-fluoride groups(P<0.05).The results suggested that young rats are more sensitive to high-dose fluoride,which can reduce bone quality in rats.The negative effects on bone quailty of rats were gradually displayed as the prolongation of the period of fluoride.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Tissue Engineering Research Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Tissue Engineering Research Year: 2010 Type: Article